Senior Scientist, Bioconjugation – Oncology Targeted Discovery Chemistry, Early Oncology

Job title:

Senior Scientist, Bioconjugation – Oncology Targeted Discovery Chemistry, Early Oncology

Company

AstraZeneca

Job description

Job Title: Senior Scientist, Bioconjugation – Oncology Targeted Discovery Chemistry, Early Oncology, London UKLocation: LondonSalary: ExcellentIntroduction to role:In the Oncology Research and Development, we relentlessly follow the science, challenging the status quo to deliver more effective treatments to patients in need. Our dedication means we purposefully push back the limits of knowledge to change the practice of medicine. To ensure no patient is left behind, no matter what stage of disease. Fast-paced, it takes agility and responsiveness to stay committed in our pursuit of excellence. We work with focus to seek the unanswered questions – innovating, exciting accepted norms, quick decision-making and taking smart risks. A place of trust, it’s an opportunity to take accountability, be brave, speak up, step up and redefine Oncology, now and in the future. Be a part of improving lives. This is the time to join the team who is confident that cures for cancer are within our graspThis is an exciting opportunity for a highly motivated laboratory-based scientist to join the Bioconjugation group in Oncology Targeted Discovery (OTD) – Chemistry Site, London, UK. You will be part of a team of Bioconjugation scientists working collaboratively with other subject areas, playing a pivotal role in the delivery of robust and high-quality data to support Antibody Drug Conjugate (ADC) discovery projects within the Oncology portfolio. You should have a background in Oncology/Biology/Chemical Biology and a strong passion for experimental work and delivering data from the laboratory. You will authoritatively design and conduct laboratory experiments, develop analytical methods, analyse and report experimental data, use scientific judgment, and communicate effectively to relevant partners and supply to early-stage drug discovery decision making.Accountabilities:This is a full-time laboratory-based position to develop, optimise and scale up drug discovery research lab experiments independently by applying the techniques of Bioconjugation of small molecules to antibodies and related scaffoldsPerform routine interpretation of data with little or no guidance, with a clear understanding of its implications within drug discovery and effectively communicate to relevant partners in a clear and concise mannerWork independently within a team and collaboratively with internal and external partnersMaintain a well-developed understanding of approaches to targeted delivery of therapeutics within OncologyRemain up to date with relevant recent advances and relevant technology including published papers/patents with peersAuthoring and reviewing relevant documents including laboratory notebooks, protocols and reportsEnsures own work, and work of peers, follows Good Laboratory Practice, Safety, Health and Environment standards and all other relevant internal AstraZeneca standards and external regulationsEssential Skills/Experience:PhD or equivalent experience in Chemistry, Biochemistry, Bio/Chemical engineering or relevant subject area or M.Sc/B.Sc in above fields with relevant industrial experienceStrong background in chemistry and protein biochemistryHands on experience in protein/bioconjugate characterisation by UV/Vis spectroscopy, size-exclusion/hydrophobic interaction/ion exchange chromatography HPLC and LCMSExperience with completing preparative chromatography purifications using AKTA and TFF systemsA track-record of protein/related scaffold modification experienceDesirable Skills/Experience:Experience with Antibody-drug conjugatesKnowledge and strong understanding of developing and optimising robust analytical methods for protein/bioconjugate characterisationBiophysical Characterization of protein/related conjugatesSo, what’s next?Please complete your application before the below closing date ( 21 March 2025)We look forward to hearing from you.Where can I find out more?Follow AstraZeneca on LinkedInFollow AstraZeneca on FacebookFollow AstraZeneca on InstagramJoin us today and be a part of the change!Date Posted 07-mar.-2025Closing Date 20-mar.-2025Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.

Expected salary

Location

London

Job date

Sat, 08 Mar 2025 23:15:37 GMT

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