Cancer Research UK
Job title:
Senior Scientist – Functional Genomics
Company
Cancer Research UK
Job description
Transformative methods. Inquisitive minds. Life-changing foresight.Senior Scientist – Functional GenomicsStarting salary: £41,700- £46,500 (depending on experience)plusDirectorate: Research & InnovationContract: PermanentHours: Full time 35 hours per week (Flexible working requests will be considered)Location: Cambridge, UK, Functional Genomics Centre, Cambridge, UKClosing date: 26 June 2024 23:55This vacancy may close earlier if a high volume of applications is received or once a suitable candidate is found, therefore we strongly recommend that you apply early to avoid disappointment. If you require more time to apply as part of a reasonable adjustment, please contact as soon as possible.Recruitment process: Telephone Screening + Face to Face Interview at the labAt Cancer Research UK, we exist to beat cancer.Are you a passionate Scientist looking for the opportunity to work on exciting drug discovery projects at the world’s leading cancer research charity? This could be the perfect opportunity to utilise your expertise in a cause-driven environment helping Cancer Research to beat cancer sooner.About the teamThe established in 2019 as a collaboration between AstraZeneca and to build a centre focused on developing and applying genetic screening in the field of oncology. This role offers the unique opportunity to be part of an exciting team, operating at the forefront of research and technology development, whilst it is being applied to clinically actionable programs.About Cancer Research HorizonsAt Cancer Research UK, our focus is on beating cancer. As the world’s biggest medical research charity, we’ve helped bring eleven new cancer drugs to market. However, there is still an urgent need to bring more effective treatments to patients faster.We have recently developed a new approach to driving therapeutic innovation through the creation of Cancer Research Horizons. We have brought together Cancer Research UK’s established drug discovery teams under one organisation and leadership team, combining our unique pipeline of world class biology, cutting edge technology platforms and clinical expertise to 1) bring new treatments to patients faster and 2) tackle the biggest challenges in discovering cancer drugs by seeking out more radical ideas and embracing risk in our bid to achieve success.Based at the Babraham Research Campus, Cambridge, the Biomedical Campus in Cambridge, Granta Park in Cambridge, the Beatson Institute in Glasgow, the Francis Crick Institute in London, and Newcastle University, Cancer Research Horizons employs ~200 staff from both industrial and academic backgrounds.This role offers a unique opportunity to join an exciting team working at the forefront of research and technology development in a diverse scientific environment. You will collaborate with academia and pharma, applying cutting-edge technologies to clinically actionable programs. The ideal candidate is a strong team player with excellent communication and organizational skills, who can leverage their experience to lead projects and effectively incorporate and apply new technologies to drive project success. You’ll also be surrounded by people who are as dedicated to beating cancer as you are.What will I be doing?Design and execute pooled CRISPR screens to identify and validate potential therapeutic targets in cancer.Generate Cas9-expressing cell lines, produce lentiviral libraries, optimize screening conditions, and prepare samples for NGS.To implement experimental plans over agreed timelines and to ensure that the objectives of the projects are met.Lead on scientific builds to advance our functional genomics capabilitiesStay up-to-date with technological advancements and apply them to improve experimental design and assay performance.What are you looking for?Experience using CRISPR gene-editing and performing cell culture with excellent aseptic technique.Demonstrated experience in molecular biology, and assay development/optimization, experience in NGS data analysis is a plus.Ability to work independently, contribute to experimental design, and troubleshoot effectively.Eagerness to learn new techniques quickly.Strong interpersonal skills and ability to collaborate effectively in a team.Practical experience in CRISPR screening for target identification/validation is highly desirable.Experience with disease-relevant cellular models (organoids, primary immune cells) and/or CRISPR base editing, perturb-seq, in vivo screening, CRISPR activation or combinatorial screening is a plus.Our organisation values are designed to guide all that we do.Bold: Act with ambition, courage and determinationCredible: Act with rigour and professionalismHuman: Act to have a positive impact on peopleTogether: Act inclusively and collaborativelyWe’re looking for people who can believe in and embody these organisation values and can use them to drive forward progress against our mission to beat cancer.If you’re interested in applying and excited about working with us but are unsure if you have the right skills and experience we’d still love to hear from you.What will I gain?We create a working environment that supports your wellbeing and provide a generous benefits package, a wide range of career and personal development opportunities and high-quality tools. Our policies and processes enable you to improve your work-life balance, take positive steps in your career and achieve your personal wellbeing goals.You can explore our benefits by visiting our .How do I apply?We operate an anonymised shortlisting process in our commitment to equality, diversity and inclusion. CVs are required for all applications; but we won’t be able to view them until we invite you for an interview. Instead, we ask you to complete the work history section of the online application form for us to be able to assess you fairly and objectively.For more information on this career opportunity please or contact us at .For more updates on our work and careers, follow us on: , , , and .Our vision is to create a charity where everyone feels like they belong, benefits from and participates in, the work we do. We actively encourage applications from people of all backgrounds and cultures, in particular those from ethnic minority backgrounds who are currently under-represented.We want to see every candidate performing at their best throughout the job application process, interview process and whilst at work. We therefore ask you to inform us of any concerns you have or any adjustments you might need to enable this to happen. Please contact or 020 3469 8400 as soon as possible.Unfortunately, we are unable to recruit anyone below the age of 18, so that we can protect young people from health & safety and safeguarding risks.
Expected salary
£41700 – 46500 per year
Location
United Kingdom
Job date
Fri, 14 Jun 2024 05:18:14 GMT
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