Senior Scientist, Physicochemical Development

Job title:

Senior Scientist, Physicochemical Improvement

Firm

AstraZeneca

Job description

Are you able to make a constructive influence on altering sufferers’ lives? Be part of our Analytical Sciences workforce in Biopharmaceuticals R&D, the place we play a vital position in advancing new biopharmaceutical drug initiatives. We function in a extremely cross-disciplinary surroundings, collaborating carefully with scientists throughout Biopharmaceutical Improvement and the broader AstraZeneca organisation.Accountabilities:As a Senior Scientist, you’ll help the characterization of a broad portfolio of biologics, utilizing state-of-the-art mass spectrometry methods. You’ll establish and monitor potential essential high quality attributes in help of upstream, downstream and formulation growth. Additionally, you will discover new applied sciences/capabilities to boost our product understanding all through the manufacturing course of. As a topic professional, you’ll be concerned in driving {our capability} construct, together with proteomics and structural mass-spectrometry. You’ll characterize Analytical Sciences at cross-functional interfaces, each domestically and globally.Important Abilities/Expertise:PhD, MSc, BSc (or equal) in biochemistry, chemistry or biotechnology with a robust understanding of protein chemistryExpertise utilizing LC-MS to characterize sequence variants, post-translational modification evaluation and chemical modifications of biologicsConfirmed monitor report of working collaboratively in a forward-thinking, disruptive and cross-disciplinary/cross-functional surroundingsExpertise with main methodology qualification and/or tech switch between a number of websitesConfidence in independently growing molecule particular methodology and evaluating new applied sciencesExcessive-quality reporting/presentation of analytical knowledge to non-expert audiencesFascinating Abilities/Expertise:Sensible expertise with proteomics workflows together with processing and interpretation of proteomic knowledge unitsSensible expertise analyzing a spread of biotherapeutic modalities, together with proteins/nucleic acid/nano particles/virus capsidsExpertise with physicochemical strategies similar to N-linked glycan evaluation, chromatography (SEC,IEC, RP), electrophoresis (SDS-PAGE and c-IEF) to analyse therapeutic proteinsExpertise of Biopharmaceutical Improvement and CMC associated actions together with expertise supporting regulatory filingsFamiliarity with structural MS (HDX-MS, Native-MS and XL-MS, FPOP)At AstraZeneca, we observe the science to discover and innovate. We’re working in direction of treating, stopping, modifying and even curing a few of the world’s most complicated ailments. We’ve got constructed our enterprise round our ardour for science. Now we’re fusing knowledge and know-how with the newest scientific improvements to realize the subsequent wave of breakthroughs. It is our mixture of curiosity and braveness that drives us. We rejoice our successes and failures alongside the best way. We work seamlessly as one, increasing our horizons by uniting one of the best from academia, biotechs and the business. That is the place to construct a significant profession as we push the boundaries of science to ship life-changing medicines.Prepared to hitch us? Apply now to be a part of a workforce that makes a much bigger influence on sufferers’ lives!Date Posted 28-Mar-2024Closing Date 11-Apr-2024Our mission is to construct an inclusive and equitable surroundings. We would like folks to really feel they belong at AstraZeneca and Alexion, beginning with our recruitment course of. We welcome and think about purposes from all certified candidates, no matter traits. We provide cheap changes/lodging to assist all candidates to carry out at their greatest. When you’ve got a necessity for any changes/lodging, please full the part within the utility kind.

Anticipated wage

Location

Cambridge

Job date

Sat, 30 Mar 2024 03:48:13 GMT

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