Senior Scientist, Protein Sciences & Analytics, Biologics Engineering – Affinity Biophysics

Job title:

Senior Scientist, Protein Sciences & Analytics, Biologics Engineering – Affinity Biophysics

Company

AstraZeneca

Job description

Senior Scientist, Protein Sciences & Analytics, Biologics Engineering-Affinity Biophysics-Location: Cambridge, UKSalary: Competitive with excellent benefitsPioneer a new future to meet global healthcare challenges.AstraZeneca is a science-led, global biopharmaceutical company, with a focused portfolio in core therapies. At AstraZeneca we turn ideas into life changing medicines. We are committed to improving the health and lives of people across the globe, through our research and development platform, and a growing late-stage pipeline. Working in over 100 countries, we have strength in emerging markets, and our medicines are used by millions of patients and clinicians worldwide. Working here means being results-oriented and working together to make the impossible a reality.We are seeking a highly skilled and motivated Protein-Protein Interactions Expert to join our team at AstraZeneca. The successful candidate will be responsible for using Surface Plasmon Resonance (SPR) and other pioneering techniques to study and characterize protein-protein interactions, contributing to the advancement of our drug discovery and development programs.In this role (Senior Scientist) you will be involved in protein-protein interactions assay development, characterisation of biologics molecules and will work as part of a multi-disciplinary team in a primarily lab-based role.Biologics Engineering Function in the UK is based at our new state-of-the-art Discovery Centre (DISC) located on the Cambridge Biomedical Campus.Biologics Engineering is responsible for the discovery and optimisation of biological candidate drugs to support all therapy area drug discovery pipelines and for the development of in-house biologics discovery platforms and novel drug modalities to support future drug discovery efforts.We are seeking a highly motivated Senior Scientist to support our biologics discovery pipeline and provide protein affinity and biophysical characterisation expertise to support drug discovery and technology development projects across all therapeutic areas at AstraZeneca. This primarily lab-based role involves working as part of a multi-disciplinary team involved in production and characterisation of biologics, interacting with multiple departments (e.g., the therapy areas and Data Science & Artificial Intelligence).If you are passionate about unravelling the complexities of protein-protein interactions and are eager to contribute to the development of life-changing therapeutics, we would love to hear from you. Please submit your CV and a cover letter detailing your relevant experience and expertise.Key Responsibilities:

• Design and measure the affinity of protein-protein interactions via surface, solution and cell-based methods e.g. using Biacore, Carterra, KinExA and LigandTracer instruments, to support the characterisation of therapeutic molecules.
• Analyze and interpret experimental data to provide insights into the molecular mechanisms of protein-protein interactions.
• Collaborate with multidisciplinary teams to support drug discovery projects by providing expertise in protein-protein interactions.
• Stay abreast of the latest scientific and technological advancements in the field of protein-protein interactions and contribute to the implementation of new techniques and methodologies.

Essential Requirements:

• PhD with relevant experience or BSc/higher degree with equivalent lab-based experience.
• Hands-on experience designing and determining affinity measurements of protein-protein interactions via surface, and solution methods e.g., Biacore, and Carterra, as well as the analysis of large data sets.
• Extensive experience of conducting protein chemical modifications and biophysical protein characterisation by e.g. SDS-PAGE, Western blotting and HPLC-SEC.
• Excellent understanding of the theoretical concepts of molecular interactions and applying these to experimental design in support of drug and technology projects.
• Ability to provide solutions to a variety of complex problems e.g., able to troubleshoot affinity determinations from complex interactions.
• Ability to optimize protocols, troubleshoot, interpret experimental results/data, and maintain accurate, high quality and up-to-date experimental records.
• Excellent communication and collaboration skills, with the ability to work effectively in a multidisciplinary team environment and with an ability to quickly learn and embrace new technologies.

Desirable Requirements:

• Experience with other biophysical characterisation techniques, such as BLI (Octet), KinExA, LigandTracer, MST and mass spectrometry.
• Experience with molecular biology, protein purification and cell culture techniques
• Experience working in a high-throughput environment, as well as using high-throughput automation and liquid-handling systems e.g., Hamilton Robotics liquid handlers.
• A background in drug discovery and development in the pharmaceutical industry.
• Experience of leading/co-leading and/or managing research projects.
• Experience with Signals ELN and Genedata Biologics platforms.

Are you ready to make a meaningful and lasting difference in the world? Apply now!Closing Date: 31st July 2024Where can I find out more?Follow AstraZeneca on LinkedInFollow AstraZeneca on FacebookFollow AstraZeneca on InstagramWhen we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That’s why we work, on average, a minimum of three days per week from the office. But that doesn’t mean we’re not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.Date Posted 17-Jul-2024Closing Date 31-Jul-2024Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.

Expected salary

Location

Cambridge

Job date

Fri, 19 Jul 2024 04:04:58 GMT

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