Sr Scientist, Translational Research (Neuroscience & Neurodegenerative Disease)

Job title:

Sr Scientist, Translational Research (Neuroscience & Neurodegenerative Disease)

Company

Orchard Therapeutics

Job description

Location: London, UKReporting to: Director, Translational ResearchJob summaryOrchard Therapeutics is a pioneering company in the field of cell and gene therapy where the Translational Research Department develops novel and innovative applications of Orchard’s platform of hematopoietic stem cell gene therapy. This role will be based in West London in our Hammersmith Research facility within our global headquarters.The Senior Scientist in Neurology, will perform experimental laboratory duties related to the design and development of preclinical research models to evaluate the feasibility and the efficacy of cell and gene therapies in neurodegenerative disease models and/or other neuroscience research programs under development by the Translational Research Team. The role will specifically involve performing preclinical research to develop a variety of analytical techniques, and to develop and implement the use of innovative in vitro cell culture models and ex vivo models of disease, to drive the discovery and validation of therapeutic targets addressable by gene therapy.The Senior Scientist will work closely with the Research Director and other scientists to design and plan experiments, establish and run experimental studies, ensure compliance in documentation, and be responsible for analysis, interpretation, presentation and reporting of experimental studies.Key Elements and Responsibilities

• Contribute towards the design, planning and conduct of experimental pre-clinical research models and studies for assigned research programs.
• Perform in vitro and ex vivo experiments in the laboratory, including data analysis, interpretation and presentation.
• Oversee the preparation, review and completion of study reports and protocol SOPs.
• Work with other scientists to develop new ideas and solutions to research questions.
• Contribute to the overall activities of the research team and department as required, including laboratory duties, attendance and participation in group and department meetings.

RequirementsRequired Knowledge and Skills

• Extensive research experience of working within the field of brain diseases and/or neurodegeneration:

o extensive understanding of in vivo models of brain diseases (genetics, pathology, biomarkers)o extensive experience in in vitro cell culture, using cell lines, primary cells and cell isolation methodso experience in immunohistochemistry techniques and image analysis

• Experience in the practical application of advanced in vitro and ex vivo immunological assays and analytical methods including but not limited to flow cytometry, ELISA, western blot and immunofluorescence (IF), PCR.
• Keen attention to detail, with an excellent analytical ability to interpret results and study report/ presentation writing.
• Ability to work in a laboratory independently and as part of a team, to design and develop protocols and SOPs.
• IT skills including Word, Excel, PowerPoint, Graphpad, experience of working with an ELN would be preferred.
• Ability to present own work in a clear and structured way at team and departmental level meetings.

Qualifications/ ExperienceCandidate must possess:

• PhD (or equivalent) with recent or active experience within research in a neuroscience setting.
• At least 5 years of experience of laboratory work in cell biology, molecular biology and preclinical disease models is essential.

Expected salary

Location

London

Job date

Mon, 13 Jan 2025 23:18:58 GMT

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