Structural Biologist with cryo-EM Experience

Job title:

Structural Biologist with cryo-EM Experience

Company

GlaxoSmithKline

Job description

Structural biologist with cryo-EM ExperienceThe UK Structural & Biophysical Sciences (SBS) group is a global multi-disciplinary department within GSK R&D that provides molecular insights into drug discovery for small molecule, oligonucleotide, biopharmaceutical and vaccine programs.We are looking for structural biologists with a strong knowledge of electron microscopy, especially applied to small molecule drug development or vaccine research.Motivated to work within a team environment the individual will want to apply their talents to drive impact on therapeutic projects by working closely with others. With a passion to remain current in this rapidly moving area, you are likely to have exceptional strengths in one to two specific aspect of EM. Whether this be instrument knowledge, challenging sample optimisation, skills in software development and processing, or creativity in addressing complex problems, we are keen to understand the abilities that set you apart.Recognising the value of maintaining excellence GSK supports individual career paths and personal development planning. Our goal is to build diverse teams that work together to address key drug discovery challenges with the best scientific insights possible.There are multiple positions available. The roles can encompass all or some of these activities :

• Deliver structural biology results as part of integrated cross-discipline teams to support drug discovery project decisions.
• Design experiments to ask critical program question using structural and biophysical approaches and effectively coordinate this within the department.
• Contribute to the cryo-EM infrastructure of the department, such as supporting the running of the EM facility or assisting with the computational structural biology infrastructure e.g. testing and embedding new software and automation of computational EM pipelines.
• Building a collaborative environment, contributing to the innovation and high productivity of the department to advance the application of structure and biophysics in drug discovery.

Why you?Basic Qualifications & Skills:We are looking for professionals with these required skills to achieve our goals:Preferred Qualifications & Skills:

• A background in a biological, biochemical or physical sciences discipline, with at least PhD level or equivalent experience.
• Extensive knowledge of all stage’s single particle cryo-EM process from protein purification to grid optimisation, data-processing, 3-D reconstruction and structure interpretation.
• Demonstrated exceptional track record of success and expertise in one or two specific area of the cryo-EM process.
• Success with multiple high-resolution structures including small proteins and ideally membrane protein complexes.
• Experience with operation of screening and high-resolution data-collection microscopes.
• Excellent organisation, interpersonal, communication and team working skills.

Please note the following skills are not necessary, just preferred, if you do not have them, please still apply:

• Extensive experience of cryo-EM sample preparation and optimisiation including cross-linking and extending to cryo-ET, ideally including expertise in protein purification.
• Expertise in working with challenging systems including membrane proteins and RNA.
• Experience in automating single particle processing or cryo-ET processing.
• Significant experience in other structural biology or biophysical techniques.
• Experience of scientific leadership to influence programs of research.
• Evidence of ability to coordinate projects with interconnecting activities.

Closing Date for Applications: 14th October 2024Please take a copy of the Job Description, as this will not be available post closure of the advert.When applying for this role, please use the ‘cover letter’ of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people over the next 10 years. R&D is committed to discovering and delivering transformational vaccines and medicines to prevent and change the course of disease. Science and technology are coming together in a way they never have before, and we have strong tech-enabled capabilities that allow us to build a deeper understanding of the patient, human biology and disease mechanisms, and transform medical discovery. We are revolutionising the way we do R&D. We’re uniting science, technology and talent to get ahead of disease together.Find out more:.Why GSK?Uniting science, technology and talent to get ahead of disease together.GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves – feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.As an Equal Opportunity Employer, we are open to all talent. In the US, we also adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to neurodiversity, race/ethnicity, colour, national origin, religion, gender, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class*(*US only).We believe in an agile working culture for all our roles. 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Expected salary

Location

Stevenage, Hertfordshire

Job date

Tue, 24 Sep 2024 22:38:15 GMT

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