Technical Specialist

Job title:

Technical Specialist

Firm

Wellcome Sanger Institute

Job description

Do you wish to assist us enhance human well being and perceive life on Earth? Make your mark by shaping the longer term to allow or ship life-changing science to unravel a few of humanity’s best challenges.Senior Analysis Assistant – Technical SpecialistOpen Targets Validation LaboratoryFastened time period for 12 months (Maternity Cowl)In regards to the Position:
We’re searching for an enthusiastic and motivated scientist with experience in experimental oncology to supply experimental, scientific and operational assist to the Open Targets Validation Lab on the Wellcome Sanger Institute. Inside the Open Targets Consortium , we work with world-leading specialists from each academia and trade to run discovery tasks for targets of recent therapeutic potential, and the mission of the Open Targets Validation Lab is to supply extra experimental proof to assist the relevance of those targets in illness biology. This place presents an thrilling alternative to work on a venture that contains the biggest, so far, dataset of twin CRISPR perturbations (65K pairs, 45 cell traces, 2 tissue varieties) and validate therapeutic hypotheses that exploit artificial lethality in most cancers.The position:You’ll lead the execution of experimental workflows to evaluate targets rising from tasks in our Oncology portfolio. You’ll assist the Open Targets Validation Lab to validate putative therapeutic targets, utilizing CRISPR-Cas9 mediated perturbation in experimental most cancers mannequin methods. Your work would require using liquid dealing with tools to facilitate medium-throughput processing of a number of targets in a number of cell traces, and using state-of-the artwork live-cell imaging and biochemical readouts to tell on the capabilities of those targets in most cancers cell biology.You’ll work carefully with the lab head and tutorial staff that leads the goal identification venture to prioritise targets for validation, in addition to bioinformaticians and contribute to knowledge evaluation and knowledge interpretation. Moreover, you’ll have the chance to interact with trade companions in maximising the translational relevance of this work.This position is a good alternative for candidates obsessed with translational analysis and a want to work on the intersection of academia and trade.The place is funded for 12 months.About Us:Open Targets goals to supply proof on the organic validity of therapeutic targets and supply an preliminary evaluation of the effectiveness of a pharmacological intervention technique constructed round these targets. To realize this, Open Targets helps a number of large-scale experimental tasks that generate potential goal lists, and whereas a small variety of these targets are adopted up by the unique venture staff, capability constraints typically depart many doubtlessly attention-grabbing outcomes under-investigated.The Open Targets Validation Lab goals to bridge the hole between large-scale goal identification tasks and uptake of nominated targets into drug growth pipelines, by way of the implementation of a large-scale goal validation framework. Utilizing probably the most cutting-edge applied sciences in genome modifying and gene/protein modulation, the Open Targets Validation Lab is working in a scientific, medium-throughput method to supply independently-generated proof for these targets and their mechanisms of motion.Important Expertise:

• Diploma in Mobile biology, Most cancers biology or associated self-discipline
• PhD or post-graduate diploma in a related analysis space
• Intensive analysis expertise and technical competence in mammalian cell tradition for mobile biology and/or experimental oncology (expertise with most cancers cell traces can be a plus)
• Intensive expertise in a cell biology lab surroundings and in-depth understanding of basic ideas in assay growth and optimisation (e.g. embody QC implementation, use of experimental controls, understanding of assay detection ranges, multiplexing)

• Expertise in gene modulation applied sciences, with a give attention to CRISPR-Cas9, and their supply to cells by way of transduction and transfection
• Expertise in real-time imaging strategies
• Laptop literate with expertise in knowledge evaluation, visualisation and presentation
• Confirmed monitor document of delivering complicated experimental scientific tasks
• Means to speak concepts and scientific findings successfully in an interdisciplinary surroundings
• Fluent in written and spoken English
• Wonderful prioritisation and time administration abilities, and talent to organise personal workload

• Means to make use of initiative, troubleshoot and work independently on agreed duties
• Element-oriented and extremely organised, together with holding glorious scientific data
• Wonderful, team-oriented work ethic with sturdy interpersonal abilities.

Desired Expertise:

• Analysis expertise/in-depth understanding of arrayed phenotypic screening
• Information of colorectal most cancers and/or breast most cancers biology
• Understanding of the ideas of artificial lethality in most cancers
• A confirmed monitor document of productiveness and innovation in academia or trade
• Ardour for translational analysis and advancing scientific discoveries to new therapies.

Different Info:Casual inquiries might be made on to Panos Zalmas, head of the Open Targets Validation Lab (panos.zalmas@sanger.ac.uk)Wage: £40,523 – £48,142Contract: 12 months (maternity cowl)Hybrid Working at Wellcome Sanger:We recognise that there are a lot of advantages to Hybrid Working; together with an improved work-life steadiness, with extra targeted time, in addition to the power to organise working time in order that collaborative alternatives and staff discussions are facilitated on campus. The hybrid working association will differ for various roles and groups. The character of your position and the kind of work you do will decide if a hybrid working association is feasible.Equality, Variety and Inclusion:We goal to draw, recruit, retain and develop expertise from the widest attainable expertise pool, thereby gaining perception and entry to totally different markets to generate a larger impression on the world. We have now a with the next employees networks, LGBTQ+, Mother and father and Carers, Incapacity and Race Fairness to convey individuals collectively to share experiences, supply particular assist and growth alternatives and lift consciousness. The networks are additionally a spot for allies to supply assist to others.We wish our individuals to be whoever they wish to be as a result of we consider individuals who convey their greatest selves to work, do their greatest work. That’s why we’re dedicated to creating a really inclusive tradition at Sanger Institute. We’ll contemplate all people with out discrimination and are dedicated to creating an inclusive surroundings for all workers, the place everybody can thrive.Our Advantages:We’re proud to ship an awarding campus-wide worker wellbeing technique and programme. The significance of excellent well being and adopting a more healthy way of life and the dedication to scale back work-related stress is strongly acknowledged and recognised at Sanger Institute.Sanger Institute turned a signatory of the Worldwide Technician Dedication initiative In March 2018. The goals to empower and guarantee visibility, recognition, profession growth and sustainability for technicians working in increased schooling and analysis, throughout all disciplines.

Anticipated wage

£40523 – 48142 per 12 months

Location

Hinxton, Cambridgeshire

Job date

Sat, 06 Apr 2024 03:53:18 GMT

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