The advancement of aqueous-Scanning Thermal Microscopy (a-SThM): Nano-scale measurement and manipulation of heat for healthcare

The ability to measure and manipulate heat is fundamental when studying biological processes, chemical reactions and even fundamental physics. By changing temperature, biological, chemical and physical processes can be sped-up, slowed-down or even stopped. Likewise, many processes result in the generation or consumption of thermal energy so can be monitored by measuring temperature. However, the accurate control and measurement of temperature at the micro- and nano-scale is very difficult, with no single approach offering a perfect solution.

Our research group are world leaders in the field of Scanning Thermal Microscopy (SThM) a powerful technique used to study heat on the nanometer scales. This technique is based around Atomic Force Microscopy (AFM) and can be used to locally heat regions of a sample, making it ideal for studying the impact of microscopic ‘hot spots’. Recently, we have developed the world’s first SThM capable of using conventional probes in biologically benign environments. One significant application for this tool is studying the highly promising new technology, called ‘nanoparticle-mediated photothermal therapy’, where nanoparticles absorb light and generate heat to kill cancer cells directly or release pre-loaded therapeutic drugs. However, the mechanism of heat-induced death is poorly understood, mainly because of unknown heat or temperature profiles around nanoparticles within cells.

In this project, the PhD student will extend the applications of our cutting edge aqueous-SThM to explore the photothermal process of novel nanostructures in liquid environments and their implications in tumour treatment. The student will join a vibrant, highly multi-disciplinary team located in the state-of-the-art Advance Research Centre. Training in advanced microscopy, image analysis, deep learning, and the handling of biological samples will be provided.

We are seeking a motivated candidate to apply for a James Watt School of Engineering Doctoral studentship to join an internationally leading research group. SThM measurements will be carried out in the Advanced Research Centre at the University of Glasgow, with sample/probe production taking advantage of the world-leading James Watt Nanofabrication Centre (JWNC). Applicants should have at least a 2:1 or equivalent Masters level qualification and ideally have experience in the use/development of instrumentation. This would particularly suit candidates with a degree in Engineering, Physics, Chemistry, biophysics or similar. 

Funding, for UK and Irish students, is available for 3.5 years and includes a stipend and fees (£19,237 plus £4,786 fees per annum) at RCUK levels from October 2024.  Informal enquires and full application (curriculum vitae, cover letter and contact details of two referees) to Dr. Phillip Dobson and Prof Huabing Yin.