The human microbiome: Interactions with diet, health, and performance

We have previously shown that ingestion of green leafy and root vegetables such as beetroot can improve markers of cardiovascular health [1,2] and exercise performance [3,4]. The vegetables absorb nitrate from the soil, which the body can convert to nitrite by the actions of bacteria that reside in the mouth. The nitrite can then be converted to nitric oxide, a potent signalling molecule that plays a key regulatory role in vascular function, muscle metabolism, and immune function. Our recent work has demonstrated that the composition of the oral microbiome can influence how an individual responds to dietary nitrate supplementation [5]. We have further shown that regular ingestion of nitrate-rich vegetables alters the abundance of nitrate-reducing bacteria and improves markers of oral and cardiovascular health [6,7]. Conversely, antibacterial mouthwash abolishes the oral bacteria and increases blood pressure [8].

This PhD project will further explore the interplay between the composition and actions of the human microbiome and markers of human health and performance [9]. The research will encompass several studies which require the collection of biological samples and other experimental outcomes in human participants before and after nitrate and placebo supplementation. Biological samples will be analysed for markers of nitric oxide availability and the composition of the microbiome determined using next generating sequencing and bioinformatics.

 

The PhD student will receive full training in all techniques and will develop comprehensive and multidisciplinary knowledge and practical skills.

Eligibility

This scholarship is open to all students, whether home, EU or overseas.

Essential requirements:

–         First or upper second-class Honours degree (or equivalent) in Sport & Exercise Sciences, Physiology, Biomedical Sciences, Biological Sciences, Microbiology or related subjects.

–         Excellent personal, oral, and written communication skills.

Desirable qualities:

–         MSc in a relevant discipline

–         Experience in conducting research in a relevant area.

How to Apply

To apply you must complete our online application form.

Please select PhD Life Science as the programme and include your full project title and reference number (EGIS2024-LK) on your application form. Ensure that all fields marked as ‘required’ are complete.

Once have entered your personal details, click submit. You will be asked to upload your supporting documents. You must complete the section marked project proposal; please provide a written proposal (3-5 A4 pages), including a supporting statement outlining your suitability and how you would approach the project.

You must also upload your CV, a copy of your degree certificate and relevant transcripts and an academic reference in the relevant section of the application form.

You must also provide proof of your ability in the English language (if English is not your mother tongue). We require an IELTS certificate showing an overall score of at least 6.5 with no component scoring less than 6.0, or a TOEFL certificate with an overall score of at least 85, including reading 20, listening 19, speaking 20 and writing 21. Alternatively, if you have received an English-taught Bachelors or Masters degree from one of the countries listed on the UK Government Guidance under ‘Who does not need to prove their knowledge of English’, and it was obtained less than two years from your intended start date, you should provide evidence of your award that clearly states it was delivered and assessed in English language.

Please contact egis-pgr-apps@hw.ac.uk for technical support with your application.

Timeline:

Applications will be reviewed as they are received. The closing date is 28th June 2024, The successful candidate will be expected to start by October 2024.