The role of EBV in multiple sclerosis

About the research project

Epstein-Barr virus (EBV) is a double stranded DNA herpes virus that can have a profound effect on the immune system. The sero-prevalence of EBV in MS cases is nearly 100% and is associated with the greatest risk for MS among all the infectious agents that have been reviewed. It is not yet clear what determines who will develop MS following EBV infection. A better understanding of the role of EBV infection in MS pathogenesis will greatly improve diagnostic, therapeutic, preventive and reparative strategies.

To address the key knowledge gaps, the PhD candidate will work with a team of leading experts in three key areas: EBV pathogen and host genetics, neurology, and T cell immunity. The proposed aims for the project include 1) evaluate structural variations in EBV pathogen and host genome; 2) single-cell RNA sequencing analysis (scRNAseq) as well as scTCR sequencing on LCL-activated T cells from MS cases and healthy controls

By providing single cell level high-resolution transcriptome data to trace the complex adaptive immune response to EBV infection, we will identify T cell gene signatures specific to MS cases as well as population dynamics of T cells responding to both EBV antigens and self-antigens. This will provide invaluable insights into potential refinements of the T cell immunological therapy that our team has developed, which is now in a phase II clinical trial for MS.

Primary Supervisor

MEET DR YUAN ZHOU

Funding

Applicants will be considered for a Research Training Program (RTP) scholarship or Tasmania Graduate Research Scholarship (TGRS) which, if successful, provides:

• a living allowance stipend of $32,192 per annum (2024 rate, indexed annually) for 3.5 years
• a relocation allowance of up to $2,000
• a tuition fees offset covering the cost of tuition fees for up to four years (domestic applicants only)

If successful, international applicants will receive a University of Tasmania Fees Offset for up to four years.

As part of the application process you may indicate if you do not wish to be considered for scholarship funding.

Other funding opportunities and fees

For further information regarding other scholarships on offer, and the various fees of undertaking a research degree, please visit our Scholarships and fees on research degrees page.

Eligibility

Applicants should review the Higher Degree by Research minimum entry requirements.

Ensure your eligibility for the scholarship round by referring to our Key Dates.

Additional eligibility criteria specific to this project/scholarship:

• Applicants must be able to undertake the project on-campus

Selection Criteria

The project is competitively assessed and awarded.  Selection is based on academic merit and suitability to the project as determined by the College.

Additional essential selection criteria specific to this project:

• A Bachelor’s or Master’s degree, or its equivalent, in genetics, epidemiology, bioinformatics, or a related field
• Proficient in at least one programming language (e.g., R, Python and C++)
• Experience in analysing large multi-omics data (e.g., GWAS, WGS, scRNAseq and proteomics) and statistical modelling
• Demonstrated skills working with Unix and high-performance computer platforms
• Excellent problem-solving abilities and strong attention to detail

Additional desirable selection criteria specific to this project:

• a record of quality publications and presentations at conferences

Application process

1. Select your project, and check that you meet the eligibility and selection criteria, including citizenship;
2. Contact Dr Yuan Zhou to discuss your suitability and the project’s requirements; and
3. In your application:

• Copy and paste the title of the project from this advertisement into your application. If you don’t correctly do this your application may be rejected.
• Submit a signed supervisory support form, a CV including contact details of 2 referees and your project research proposal.

1. Apply prior to 1 February 2024.

Full details of the application process can be found under the ‘How to apply‘ section of the Research Degrees website.

Following the closing date applications will be assessed within the College. Applicants should

expect to receive notification of the outcome by email by the advertised outcome date.