Translation Research Scientist – S West lab

  • Full Time
  • London
  • Posted 2 weeks ago

Francis Crick Institute

Job title:

Translation Analysis Scientist – S West lab


Francis Crick Institute

Job description

Translation Analysis Scientist – S West labReporting to: Stephen West, Principal Group Chief and Anaid Benitez, Translation ScholarContact time period: This can be a full-time, fastened time period [18 months] place on Crick phrases and circumstances of employment.The Crick Translation FundThe mission and profitable candidate can be absolutely funded by the Translation Fund, which is generously supported by the Chris Banton Basis. The Translation Fund was established to extend alternatives for researchers engaged on translational science to progress their concepts in the direction of affect, and encourage collaborative functions that cross disciplinary boundaries, significantly on the Scientific and Bodily Sciences interfaces.DNA Recombination & Restore Lab, Group Chief: Stephen WestUndertaking Lead: Anaid BenitezThe Undertaking: Purposeful DNA Restore AssaysWe wish to recruit an enthusiastic analysis scientist to this translational programme with robust experience in biochemistry and molecular biology, occupied with growing cutting-edge diagnostic applied sciences for most cancers sufferers with DNA restore deficiencies (e.g., BRCA mutant sufferers). The profitable candidate for this explicit function can be embedded within the laboratory of Stephen West with a give attention to most cancers biology, investigating crucial components concerned in DNA harm restore.The objective of this mission is to advance personalised medication in oncology, guaranteeing that sufferers obtain the best therapies based mostly on their distinctive tumour profile, resulting in improved affected person outcomes and extra environment friendly use of healthcare sources. Our method is to develop a novel assay platform to evaluate DNA harm restore pathways. Our patent-pending know-how has been supported by excellent innovation-focused sponsors together with the Crick Translation Fund, CRUK Most cancers Analysis Horizons, MedTech SuperConnector, and Most cancers Tech Accelerator.The profitable candidate will work intently with the mission result in ship on the mission and meet the milestones set to make sure ongoing funding and transaltional success. Full help can be offered by the mission lead, group chief, and the . The candidate can be anticipated to creatively optimize the present know-how, contribute to the variation and growth of latest technological breakthroughs, and help with mental property rights and enterprise growth concerns.Strategies used will entail, however not be restricted to, commonplace biochemistry and molecular biology methods, tumour pattern processing, targeted drug-response screens, high-throuput imaging, Fluorescence-Activated Cell Sorting (FACS), and evaluation of publicly obtainable datasets. The mission can be supported by translation scientists and clinicians, trade and contract analysis organisations (CROs) as wanted. The mission will profit from shut collaboration with the Crick Science Expertise Platforms and with pharmaceutical firms within the DNA harm response (DDR) area.This can be a distinctive alternative to be a part of a very multi-disciplinary analysis mission, which can practice the next-generation of scientific leaders, geared up to succeed each in academia and trade. As a result of translational nature of the mission, there can be a chance to be taught extra about most cancers diagnostic growth by means of lively engagement with trade, clinicians, and involvement in coaching programs. You’ll work with extremely skilled colleagues and collaborators in an institute that values discovery with out boundaries. This function is designed to bridge the hole between tutorial analysis and entrepreneurship, giving the postholder a big function in not simply executing experiments but additionally contributing to the strategic course of the mission.TasksAssist the supply of the mission by enterprise laboratory analysis, growing the mission in a well timed and useful resource environment friendly method (design and execute experiments, accumulate and analyse information)Lead on the optimization of cutting-edge assays to characterize DNA restore mechanisms in varied organic fashions, taking part in a pivotal function within the evaluation of scientific utility.Lead validation efforts to determine assay reliability and accuracy, evaluating outcomes with established benchmarks.Design and execute experiments for assay adaptation to scalable codecs, contributing to the event of high-throughput capabilities.Develop and refine experimental protocols, guaranteeing the era of high-quality information and compliance with trade and regulatory requirements.Keep digital laboratory notebooks for correct documentation of analysis actions, guaranteeing information integrity and reproducibility.Take part within the analysis group by attending seminars, workshops, and conferences to remain abreast of the most recent scientific advances and foster collaborative relationships.Collaborate with cross-functional groups, together with trade companions and clinicians, to advance the interpretation of our know-how.Keep efficient communication throughout the group and exterior collaborators, guaranteeing that every one events are aligned and knowledgeable on mission progress and outcomes.Assist the mission lead with the supply of stories and displays supporting experimental outcomes to stakeholders.Help the mission lead in evaluating market tendencies and aggressive landscapes to tell strategic planning and positioning of the assay applied sciences inside the market.Assist the mission lead in establishing and nurturing relationships with potential trade companions and buyers, taking part in discussions to safe funding and partnerships that align with the mission’s commercialization path.Help the mission lead with the continual buyer discovery course of, partaking with key stakeholders to realize insights that inform the iterative growth of the know-how, guaranteeing its relevance and utility align with evolving market wants and scientific practices.Work with the mission lead and Translation Workforce to discover IP technique and commercialization pathways, guaranteeing the non-disclosure of confidential points of the know-how.Take part in skilled growth alternatives, reminiscent of workshops on innovation and entrepreneurship, to boost the industrial potential of the mission.Key expertise and competenciesThe submit holder ought to embody and reveal our core Crick values: Daring; Open; CollegialImportantCaptivated with healthcare innovation and the interpretation of bench applied sciences to boost scientific outcomesPhD or PhD equal expertise in molecular and/or mobile biology, biochemistry, or associated disciplinesDeep understanding of the molecular mechanisms of DNA double-strand break (DSB) restore and its deficiencies, together with the function of BRCA1/2 and different associated genes, in addition to scientific therapies focusing on the DNA harm response (DDR)Robust experience in mammalian cell tradition (transfection, transduction), molecular biology (molecular cloning, PCR, qPCR, and different commonplace methods), biochemistry (western blot, immunoprecipitation), Fluorescence-Activated Cell Sorting (FACS) and quantitative microscopy (immunofluorescence and picture evaluation)Monitor document of writing papers as evidenced by publications or submitted manuscripts in referred journals, with a least one first-author publication.Proof of information presentation at scientific conferencesRobust organisational abilities, glorious time administration and thorough record-keepingRobust collaborative capability and dedication to teamworkFascinatingPostdoctoral expertise in biochemistry and molecular biologyGood data and expertise in most cancers cell biology, chromatin biology, genome instability, or DNA harm and restoreExpertice in assay growthExpertise in high-throughput imaging or different methodologiesProficiency in analyzing public databasesExpertise in collaborative, cross-disciplinary analysisCuriosity in entrepreneurial coaching or participation in hackathons, bootcamps or accelerator programmes.Willingness to be taught and help with patent processes, invention disclosures, and different mental property rights concernsWillingness to be taught and help with enterprise growth points of the missionAbout UsOn the Crick, we conduct analysis on the forefront of biomedical analysis. We mix rigour with an open and collaborative tradition, and are outward-looking, reflecting our standing as a partnership of six organisations aiming to pool data, concepts and sources.We have now a large analysis portfolio with no divisions or departments, bringing biomedical researchers along with clinicians, bodily scientists and utilized scientists from our pharmaceutical companions.We intention to draw essentially the most proficient researchers and help them to sort out progressive analysis questions. Our science know-how platforms present our researchers with entry to state-of-the-art know-how and experience.We offer a superb studying atmosphere with devoted schooling programmes in public engagement with science, schooling and private growth, and a postdoc coaching programme that prepares scientists for management roles in science.All presents of employment are topic to profitable safety screening and steady eligibility to work in the UK.For those who require a visa to work within the UK we’ll assist help your utility do you have to achieve successEquality, Range & InclusionWe welcome functions from all backgrounds. We’re dedicated to offering equal employment alternatives, no matter ethnicity, nationality, gender, sexual orientation, gender identification, faith, being pregnant, age, incapacity, or civil partnership, marital or household standing. We significantly welcome functions from people who find themselves Minority Ethnic as they’re at present underrepresented within the Crick at this degree.Range is crucial to excellence in scientific endeavour. It will increase breadth and perspective, resulting in extra innovation and creativity. We wish the Crick to be a spot the place everybody feels valued and the place range is widely known and seen as a part of the muse for our Institute’s success.The Crick is dedicated to creating equality of alternative and selling range and inclusivity. All of us share within the duty to actively promote dignity, respect, inclusivity and equal remedy and it’s our intention to make sure that these rules are mirrored and applied in all methods, insurance policies and practices.Learn extra on our web site:Discover out what advantages the Crick has to supply:For extra data on our nice pay and advantages package deal please click on right here:

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Tue, 26 Mar 2024 23:25:52 GMT

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