Understanding molecular wires involved in enhancing bacterial electricity (CLARKE_U25DTP)

Primary Supervisor – Professor Thomas Clarke 

Bacteria that can produce electricity are being intensively researched due to their potential applications in metal recovery, desalination and enhanced fermentation. The model microorganism Geobacter sulfurreducens is one of the most efficient producers of bioelectricity, and the current production has been linked a single extABCD gene cluster. Our preliminary characterisation of the products of this gene cluster reveals that it contains 3 cytochromes with unique and distinct heme clusters. This project aims to fully understand the properties of these cytochromes through a range of structural and spectroscopic studies, with a view to better understanding how this gene cluster can support large electrical currents. The student will join an active lab with considerable expertise in the handling of these types of cytochromes, and will be trained in a range of different techniques, including protein expression and purification, UV spectroscopy, Protein film voltammetry, X-ray crystallography and Cryo-EM, as well as a range of other biochemical and biophysical techniques. 

The Norwich Research Park Biosciences Doctoral Training Programme (NRPDTP) is offering fully funded studentships for October 2025 entry. The programme offers postgraduates the opportunity to undertake a 4-year PhD research project whilst enhancing professional development and research skills through a comprehensive training programme. You will join a vibrant community of world-leading researchers. All NRPDTP CASE students undertake a three to 18-month placement with the non-academic partner during their study. The placement offers experience designed to enhance professional development. Full support and advice will be provided by our Professional Internship team. Students with, or expecting to attain, at least an upper second-class honours degree, or equivalent, are invited to apply. 

This project has been shortlisted for funding by the NRPDTP. Shortlisted applicants will be interviewed on 28, 29 or 30 January 2025.  

Visit our website for further information on eligibility and how to apply: https://biodtp.norwichresearchpark.ac.uk/ 

Our partners value diverse and inclusive work environments that are positive and supportive. Students are selected for admission without regard to gender, marital or civil partnership status, disability, race, nationality, ethnic origin, religion or belief, sexual orientation, age or social background. 

Entry requirements

At least UK equivalence Bachelors (Honours) 2:1 or UK equivalence Master’s degree. English Language requirement (Faculty of Science equivalent: IELTS 6.5 overall, 6 in each category). 

Mode of study

Full time

Start date

1 October 2025