NATA Chemistry Research Scientist

The Medical Analysis Council (MRC), as a part of UK Analysis and Innovation (UKRI), has invested a complete of £30m over 4 years by way of the Strategic Priorities Fund to determine a nucleic acid remedy accelerator (NATA) that may assist state-of-the-art interdisciplinary analysis to resolve essential points in nucleic acid drug supply, by way of centered NATA analysis challenges and a NATA infrastructure hub.

The NATA will concentrate on bringing collectively key stakeholders across the infrastructure hub whereas catalysing collaborative R&D exercise with centered assist to deal with important limitations dealing with oligonucleotide remedy supply to key organs. This funding will assist capability constructing by way of tools, upskilling and area experience that might be important in growing essential mass to catalyse and de-risk the event of next-generation nucleic acid therapeutics.

UK Analysis and Innovation is a brand new entity that brings collectively 9 companions to create an unbiased organisation with a powerful voice for analysis and innovation, extra info might be discovered at www.ukri.org

Band
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MRC – 4

Location
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Harwell Campus, Oxfordshire

Wage
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£39,375 – £41,843

Contract Sort
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Everlasting

Job Sort
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Science

Full Time / Half Time
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Full Time

Job Description
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The Function

That is an thrilling function in a dynamic and rising interdisciplinary crew on the NATA Hub growing new therapeutic oligonucleotides for numerous translational and collaborative initiatives. The Analysis Scientist will play a key function in designing, synthesising, and evaluating present and new chemical modifications for nucleic acid therapeutics. As well as, the Analysis Scientist will design and implement processes and workflows for nucleic acid synthesis, purification, and scale-up.

Primary Obligations

• Work intently with colleagues to carry out the design, synthesis, and analysis of oligonucleotides.
• Design and implement processes and workflows for the manufacturing of oligonucleotides.
• Take a proactive strategy to studying and implementing new methods and strategies associated to oligonucleotide improvement.
• Carry out HPLC purification of oligonucleotides and associated biomolecules.
• Handle devices, reagents, and chemical sources effectively.
• Troubleshoot and upkeep of procedures and instrumentation.
• Put together information sheets and experiences.
• Hold wonderful scientific information and implement databases.
• Keep information of the related literature.
• Recognise alternatives for the creation of mental property and cooperate in patent safety and exploitation.
• Current work internally and contribute to lab conferences.

Different Obligations

• Help the Lab Supervisor in endeavor lab administration duties resembling lab and tools upkeep, well being and security administration, reagent stock and related databases.
• Help high quality management duties when crucial
• Attend related conferences and conferences.
• Undertake any crucial coaching that contributes to the event of the principle obligations.

Particular person Specification
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Important Choice Standards

• Maintain a PhD in a biochemistry-related subject or equal analysis/business expertise.
• Expertise working with analytical methods of biomolecules, ideally nucleic acids.
• Primary information in nucleic acid bioinformatics
• Data in oligonucleotide synthesis
• Expertise in information evaluation and interpretation
• Data in HPLC purification techniques
• Interdisciplinary pursuits with an emphasis on in vitro and in vivo testing
• Glorious communication abilities and efficient engagement with colleagues and collaborators
• Excessive stage of motivation and drive with the power to multi-task and prioritise work successfully.
• Self-discipline and regard for information integrity, confidentiality, and safety
• Willingness to be taught.
• Means to put in writing scientifically.
• Able to essential considering
• Working and adhering to straightforward working procedures and expertise in course of evaluation and refinement
• Organised, hard-working with a powerful eye for element and skill to work as a part of a crew.
• Versatile and adaptable, capable of handle to vary priorities.
• Pc literacy is important for the recording and communication of outcomes.
• Means to work to deadlines and meet milestones.
• Good time administration and punctuality

Fascinating choice standards

• Primary information in molecular biology
• Excessive stage of pc literacy
• Expertise in GMP/GLP and high quality techniques
• Expertise within the synthesis of fluorescent-labelled oligonucleotides
• Expertise in massive information set evaluation and database administration

The MRC is a superb place to work and progress your profession, be it in scientific analysis or the assist capabilities.The MRC is a novel working atmosphere the place our researchers are rewarded by world class innovation and collaboration alternatives that the MRC identify brings. The MRC is a wonderful place to develop your self additional and a spread of coaching & improvement alternatives might be out there to you, together with skilled registration with the Science Council.
Selecting to return to work on the MRC (a part of UKRI) signifies that you should have entry to a complete host of advantages from an outlined profit pension scheme and wonderful vacation entitlement to entry to worker purchasing/journey reductions and wage sacrifice cycle to work scheme, in addition to the possibility to place the MRC and UKRI in your CV sooner or later.
Our success depends upon our capacity to embrace range and draw on the talents, understanding and expertise of all our folks. We welcome functions from all sections of the group no matter gender, race, ethnic or nationwide origin, faith or perception, sexual orientation, incapacity or age. As “Incapacity Assured” employers, we assure to interview all candidates with disabilities who meet the minimal standards for the emptiness.
UKRI helps analysis in areas that embrace animal well being, agriculture and meals safety, and bioscience for well being which incorporates analysis on animals, genetic modification and stem cell analysis. While chances are you’ll not have direct involvement in the sort of analysis, it’s best to contemplate whether or not this conflicts along with your private values or beliefs.
We’ll conduct a full and complete pre-employment test as an important a part of the recruitment course of on all people which are supplied a place with UKRI. This may embrace a safety test and an excessive organisations affiliation test.  The function holder might be required to have the suitable stage of safety screening/vetting required for the function.  UKRI reserves the proper to run or re-run safety clearance as required throughout the course of employment.