University of Oxford
Pay Scale: STANDARD GRADE 7
Wage: £36,024 – £41,732 every year
Location: Division of Biochemistry, South Parks Highway, Oxford
Contract sort: Fastened Time period Contract for as much as 3 years
Hours: Full Time (37.5 hours per week)
THIS IS A READVERTISEMENT AND PREVIOUS APPLICANTS NEED NOT APPLY
Concerning the function
We’re searching for to nominate a Postdoctoral Analysis Affiliate to affix the lab of Professor Peter Sarkies. Transgenerational epigenetic inheritance is more and more recognised as a approach during which modifications in gene expression may be handed throughout a number of generations with out modifications in underlying DNA sequence. Mechanistic characterisation of transgenerational epigenetic inheritance is most superior within the nematode C. elegans, the place transgenes may be silenced by small non-coding RNAs (sRNAs) and the silent state transmitted for a number of generations impartial of the preliminary set off. May such epigenetic modifications contribute to evolutionary processes as effectively? This mission goals to search out this out. It builds on prior work from the lab exhibiting that “epimutations”- spontaneous modifications in epigenetic states, can come up spontaneously in C. elegans populations and be transmitted for a restricted variety of generations. We now wish to take a look at whether or not these epimutations may drive evolutionary processes, particularly whether or not the evolution of resistance to antihelminthic medication corresponding to Ivermectin may be promoted by epigenetic modifications. We’ll evolve resistance to Ivermectin within the lab by conducting long run evolution experiments utilizing C. elegans. We’ll observe the trajectory of gene expression, small RNAs and chromatin utilizing excessive throughput sequencing throughout the timecourse of adaptation to establish epimutations that will promote resistance. This mission has the potential to redefine our understanding of the mechanisms of evolution and will show vital in tackling resistance to antihelminths in parasitic nematodes. The mission is totally funded for 3 years by the Leverhulme Belief.
This full-time fixed-term put up is funded by the Leverhulme Belief for as much as 3 years within the first occasion.
The precise beginning wage supplied will probably be based mostly on {qualifications} and related expertise acquired and also will be decided by the funding accessible.
What We Provide
Your happiness and wellbeing at work issues to us, so we provide a variety of household pleasant and monetary advantages together with:
• A superb contributory pension scheme
• 38 days annual depart
• A complete vary of childcare companies
• Household depart schemes
• Cycle mortgage scheme
• Membership to quite a lot of social and sports activities golf equipment
• Discounted bus journey and Season Ticket journey loans
The College additionally runs an infinite quantity of social teams and sports activities golf equipment for these in search of greater than only a great spot to work.
About you
You’ll have a PhD/DPhil or be close to completion of a PhD/DPhil and have familiarity with C. elegans and be passionate to use our understanding of epigenetic mechanisms to evolutionary biology. You’ll have some expertise of each computational and laboratory approaches as each will probably be required for this mission, however particular expertise of the sequencing methods is just not required. You can be enthusiastic about the opportunity of discovering new aspects of the evolutionary course of and will probably be eager to assist form the mission because it develops.
Software Course of
If you want to debate this function, please contact
Peter Sarkies
You can be required to add a supporting assertion, setting out the way you meet the choice standards, curriculum vitae and the names and make contact with particulars of three referees as a part of your on-line utility.
Solely purposes obtained earlier than 12 midday on Friday twenty second March 2024 may be thought-about with interviews for shortlisted candidates to be held as quickly as doable thereafter.
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