PhD Studentship: Aggressive Prostate Cancer in African Men: Are Microbes Involved? Investigating Decontamination, Microbiomes and Human Genomics

Major supervisor – Prof Daniel Brewer

Background

With an incidence of >1.4 million instances worldwide, prostate most cancers is the commonest non-skin most cancers in males. One in eight males will get hold of a analysis of their lifetime. Nevertheless, that is doubled in males of African descent and tends to be extra aggressive. This causes for this are unclear. One chance is that microbial variations contribute. In groundbreaking analysis, we lately discovered that sure micro organism are related to aggressive prostate most cancers.
On this PhD, you’ll search to reply the query: Are variations in prostate most cancers outcomes between ethnic teams attributable to micro organism?
Analysis Methodology

On this PhD, you’ll refine wet-lab and computational strategies for figuring out microbes in most cancers complete genome sequencing knowledge. You’ll apply these approaches to massive prostate most cancers datasets from males of various ethnic backgrounds collected by the massive, collaborative worldwide consortia through which we’re concerned. You’ll use machine studying to discover the microbiome and genomic options of most cancers. In the end, you’ll uncover necessary associations that might enhance affected person care.

Coaching

You’ll discover ways to take care of “Large Knowledge,” excessive efficiency computing, pipeline growth, and statistical analyses. We now have intensive expertise serving to individuals to develop into consultants on the forefront of most cancers, biology, and knowledge science. A coaching programme designed particularly for you’ll be created. You may be a member of UEA’s Most cancers Genetics staff, an interdisciplinary staff comprised of bioinformaticians and lab-based scientists. We’ll search Turing award funding to allow the profitable applicant to spend a part of this studentship in Sydney.

Particular person specification

A minimal of a 2:1 honour diploma in Pc Science, Physics, Arithmetic, Engineering, Organic Sciences, Biochemistry, or Biomedical Science.

The Microbes, Microbiomes and Bioinformatics (MMB) Doctoral Coaching Partnership (DTP) is open to UK and Worldwide candidates with related undergraduate levels for entry in October 2024 and gives the chance to undertake a fully-funded 4-year PhD analysis challenge supported by the UKRI Medical Analysis Council in microbiology and microbial bioinformatics.

Our distinctive and complete coaching programme empowers college students to really feel snug operating subtle pc analyses alongside laboratory work and emphasises problem-based studying in microbial bioinformatics, skilled growth and analysis expertise. All MMB DTP college students undertake a Skilled Placement.

Interviews for shortlisted candidates will happen on Wednesday 15 Might 2024.

The MRC DTP is dedicated to equality, range and inclusion. College students are chosen with out regard to age, incapacity, gender identification, marriage or civil partnership, being pregnant or maternity, ethnicity, faith or perception, intercourse or sexual orientation or social background. We worth curiosity, independence of thought, plus an inherent ability for analysis that mixes laboratory work and bioinformatics.

For data on eligibility and how one can apply: www.uea.ac.uk/phd/mmbdtp

Extra Funding Info

This challenge is awarded with a 4-year fully-funded studentship together with direct cost of tuition charges to the College, stipend for dwelling bills (2023/4 charge: £18,622) and a Analysis Coaching Help Grant for every year of the studentship.