PhD Studentship in Physiology and Pharmacology: Investigating the Therapeutic Potential of Cannabidiol (CBD) in Cardiac Fibrosis

Supervisors:  Dr. Graeme Cottrell and Professor Darius Widera

Venture Overview:

Cardiac fibrosis is a situation that’s characterised by the irregular accumulation of fibrous tissue inside the coronary heart muscle and poses a big risk to cardiovascular well being. This fibrous tissue replaces wholesome cardiac muscle cells, disrupting the pure construction and performance of the guts. Linked with hypertension, coronary heart failure, and myocardial infarction, cardiac fibrosis progresses over time, leading to coronary heart muscle stiffness, compromised pumping capability, and heightened arrhythmia dangers, finally culminating in coronary heart failure and related problems.

Thrilling breakthroughs in analysis have make clear the potential of cannabidiol (CBD) to mitigate fibrosis and irritation, providing hope for efficient therapies. But, the exact mechanisms underlying the therapeutic results of CBD stay elusive.

This ground-breaking venture seeks to unravel the therapeutic potential of CBD in combating pivotal facets of cardiac fibrosis, together with irritation ranges, cardiomyocyte differentiation, and extracellular matrix remodelling. Below the knowledgeable steerage of Graeme Cottrell and Darius Widera, profitable candidates will obtain complete coaching in cutting-edge methods spanning cell biology, biochemistry, microscopy, molecular biology, experimental design, and information evaluation.

Co-funded by MRX Medical, a number one participant in cannabinoid medicines, this collaboration gives a novel alternative to delve into drug discovery and translational science whereas gaining invaluable insights from an business perspective. Be part of us in pioneering developments in cardiovascular analysis and shaping the way forward for cardiac care.

Embark on a transformative journey, the place scientific curiosity meets real-world influence. Apply now and be a part of a collaborative effort to revolutionize cardiac fibrosis therapy.

Eligibility: 

• Candidates ought to maintain or count on to achieve a minimal of a 2:1 bachelor’s diploma or equal in a Organic Science.
• Attributable to restrictions on the funding this studentship is open to UK candidates.

Funding Particulars:   

• Begins: September 2024
• 4-year award
• Funding covers full tuition charges plus UKRI stipend (£19,237 pa for 2024/25).

Methods to apply:  

To use click on ‘Apply’ and create your account, and use the hyperlink despatched by e-mail to start out the applying course of. Through the utility course of please choose the PhD in Physiology and Pharmacology

*Vital notes*

Please quote the reference ‘DRC24-021’ within the ‘Scholarships utilized for’ field which seems inside the Funding Part of your on-line utility.

If the applying system prompts you to submit a analysis proposal, please paste within the venture title and transfer on to the following step within the utility.

Additional Enquiries:  

Please observe that, the place a candidate is profitable in being awarded funding, this can be confirmed through a proper studentship award letter; this can be supplied individually from any Supply of Admission and can be topic to straightforward checks for eligibility and different standards. 

For additional particulars please contact Dr. Graeme Cottrell ([email protected] ) and/or Prof. Darius Widera ([email protected] ).