Postdoctoral Research Associate

Job title:

Postdoctoral Research Associate

Company

University of Edinburgh

Job description

Job Description:UE07 – £39,347 – £46,974School of Biological SciencesInstitute of Quantitative Biology, Biochemistry and BiotechnologyFull Time 35 hours per weekFixed Term – 1st July 2024- 30th June 2025We are looking for an enthusiastic and talented postdoctoral researcher with an interest in chromatin biology to work on characterising interactions between non-canonical EZH2 and its protein binding partners in a disease context. This is a collaborative project between University of Edinburgh, Babraham Institute (Cambridge) and Boehringer Ingelheim (Germany).The Opportunity:An exciting opportunity has arisen to identify and characterise binding partners of non-canonical EZH2 in the context of fibrosis. EZH2 is a component of the polycomb repressor complex 2 (PRC2) that contributes to repression of gene expression. However, in certain contexts, phosphorylated EZH2 can be released from PRC2 and can activate transcription. Recent work by Boehringer Ingelheim and colleagues demonstrated that a non-canonical form of EZH2 mediates activation of fibrotic genes by acting as a transcriptional activator (Le et al. (2021) EMBO Rep 22, e52785). In collaboration with Philipp Voigt at the Babraham Institute in Cambridge and researchers at Boehringer Ingelheim, we will identify binding partners of non-canonical EZH2. The postholder will be responsible for biochemical and structural characterisation of protein-protein interactions between EZH2 and its novel partners.Your skills and attributes for success:

• Experience in recombinant protein expression, purification and characterisation.
• Experience with biochemical and biophysical assays to characterise protein-protein interactions.
• Prior training in structural biology would be an advantage.
• A research background in gene expression or chromatin biology would be an asset.

As a valued member of our team you can expect:

• A competitive salary of £39,347 – £46,974

• An exciting, positive, creative, challenging and rewarding place to work.
• To be part of a diverse and vibrant international community
• Comprehensive Staff Benefits, such as a generous holiday entitlement, a defined benefits pension scheme, staff discounts, family-friendly initiatives, and flexible work options. Check out the full list on our

(opens in a new tab) and use our reward calculator to discover the total value of your pay and benefitsChampioning equality, diversity and inclusionThe University of Edinburgh holds a Silver Athena SWAN award in recognition of our commitment to advance gender equality in higher education. We are members of the Race Equality Charter and we are also Stonewall Scotland Diversity Champions, actively promoting LGBT equality.Prior to any employment commencing with the University you will be required to evidence your right to work in the UK. Further information is available on our (opens new browser tab)The University is able to sponsor the employment of international workers in this role. If successful, an international applicant requiring sponsorship to work in the UK will need to satisfy the UK Home Office’s English Language requirements and apply for and secure a Skilled Worker Visa.Key dates to noteThe closing date for applications is 18 June 2024.Unless stated otherwise the closing time for applications is 11:59pm GMT. If you are applying outside the UK the closing time on our adverts automatically adjusts to your browsers local time zone.Interviews dates TBC.About Us: As a world-leading research-intensive University, we are here to address tomorrow’s greatest challenges. Between now and 2030 we will do that with a values-led approach to teaching, research and innovation, and through the strength of our relationships, both locally and globally.About the Team:As the modern inheritors of our 400-year-old reputation for excellence, our staff and students contribute to a vibrant academic community whose visions are shaping tomorrow’s world. The School of Biological Sciences is at the leading edge in teaching, research and innovation. Independent rankings such as the Times Higher Education consistently place us amongst the top 25 universities in the world for biological sciences. We aim to ensure that our culture and systems support flexible and family-friendly working and to recognise and value diversity across all our staff and students. The School has an active programme offering support and professional development opportunities for all staff. We place a particular focus on development for early-career researchers (postgraduate and postdoctoral research staff and personal fellowship holders), offering mentoring and an active ‘BioDocSoc’ organisation that brings together researchers for networking, events and training opportunities.The School of Biological Sciences holds a Silver Athena SWAN award in recognition of our commitment to advance the representation of women in science, mathematics, engineering and technology.Our contains more information about the School.

Expected salary

£39347 – 46974 per year

Location

United Kingdom

Job date

Wed, 05 Jun 2024 23:11:21 GMT

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