Research Fellow

Organic Sciences
Location: St John’s Campus
Wage:

£37,100 to £41,732
Put up Sort:  Full Time
Contract Sort: Fastened Time period
– 12 Months
Marketed On:  Wednesday 23 August 2023
Closing Date:  Sunday 24 September 2023
Interview Date: 

To be confirmed
Reference:  SSE2304

Analysis Fellow: RNAi-based instruments to unlock useful genomics of obligate oomycete plant pathogens. 

A postdoc place is out there within the Professor Mahmut Tör group on the Faculty of Science and the Atmosphere, College of Worcester to work on an NSF-funded undertaking in collaboration with groups at Virginia Tech. The appointee will deploy state-of-the-art strategies to the event of instruments for strong, cost-effective of RNAi by way of utility of dsRNA to suspensions of spores, and to optimize these protocols for applicability to a spread of downy mildew species. We are going to start by testing whether or not bare, E. coli-transcribed RNAs (NECT-dsRNAs) are as environment friendly as brief, chemically synthesized dsRNAs (SS-dsRNAs), and we are going to optimize quite a lot of parameters that might affect the efficacy of gene silencing. 

Our analysis program focuses on;

1) Evaluating silencing efficacy of SS-dsRNAs to NECT-dsRNAs and optimize size, dose, and goal area of NECT-dsRNAs; 

2) Quantifying dsRNA internalization;

3) Evaluating silencing efficacy of “bare” dsRNA and dsRNA protected by E. coli minicells;

4) Take a look at effectivity of multiplexed dsRNA to concurrently silence a number of genes.

Candidates ought to have a PhD or submitted their thesis within the above-mentioned areas with a wonderful document of peer-reviewed publications and powerful oral/written communication abilities. 

For casual queries relating to this position please contact Mahmut Tor, Professor, Chair of Molecular Plant and Microbial Biology on m.tor@worc.ac.uk

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